Sarcopenia and Neuropsychiatric Symptoms in Alzheimer's Patients
Author Information
Author(s): Zeng Derong, Zhang Nan, Qi Bingbing, Kawasaki Teruaki, Akiguchi Ichiro, Kinoshita Ayae
Primary Institution: Kyoto University
Hypothesis
What is the association between sarcopenia and neuropsychiatric symptoms in older adults with Alzheimer’s Disease?
Conclusion
Sarcopenia may contribute to the development or worsening of certain neuropsychiatric symptoms in Alzheimer's patients.
Supporting Evidence
- Sarcopenia was assessed using the Asian Working Group for Sarcopenia criteria.
- Logistic regression analyses revealed significant associations between sarcopenia and aberrant motor behaviors.
- Logistic regression analyses revealed significant associations between sarcopenia and nighttime disturbances.
- Age emerged as a significant predictor for eating disturbances.
Takeaway
Sarcopenia, which is when muscles weaken, might make some mental health problems worse for older people with Alzheimer's.
Methodology
Data from 110 participants were assessed using the Asian Working Group for Sarcopenia criteria and analyzed with logistic regression models.
Limitations
Further research is needed to understand the underlying mechanisms.
Participant Demographics
Participants had a mean age of 83.15 years and a mean MMSE score of 20.69.
Statistical Information
P-Value
p=0.0141 for aberrant motor behaviors, p=0.0194 for nighttime disturbances, p=0.1248 for eating disturbances, p=0.00869 for age.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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