Null Genotypes of GSTM1 and GSTT1 Contribute to Risk of Cervical Neoplasia
Author Information
Author(s): Gao Lin-Bo, Pan Xin-Min, Li Li-Juan, Liang Wei-Bo, Bai Peng, Rao Li, Su Xiao-Wei, Wang Tao, Zhou Bin, Wei Yong-Gang, Zhang Lin
Primary Institution: West China Institute of Women and Children's Health, Sichuan University
Hypothesis
Do GSTM1 and GSTT1 polymorphisms increase the risk of cervical neoplasia?
Conclusion
The null genotypes of GSTM1 and GSTT1 polymorphisms are associated with a significantly increased risk of cervical neoplasia.
Supporting Evidence
- The null genotype of GSTM1 was associated with an increased risk of cervical neoplasia (OR=1.40).
- The null genotype of GSTT1 was associated with an increased risk of cervical neoplasia (OR=1.30).
- Individuals with dual null genotype had a significantly increased risk of cervical neoplasia (OR=1.72).
- Subgroup analyses showed increased risks in Asian populations for both GSTM1 and GSTT1.
- Studies with DNA extracted from white blood cells showed increased risks for GSTM1.
- Significant heterogeneity was observed across studies.
Takeaway
Some people have a gene that doesn't work properly, which can make them more likely to get a certain kind of cancer called cervical neoplasia.
Methodology
This study is a meta-analysis combining data from 25 case-control studies to evaluate the association between GSTM1 and GSTT1 polymorphisms and cervical neoplasia risk.
Potential Biases
Potential confounding factors such as age, sexual habits, and menopausal status could not be ruled out due to unadjusted data.
Limitations
There is significant heterogeneity between studies and a relatively small sample size in some analyses.
Participant Demographics
The studies included participants from various ethnic backgrounds, primarily Asians and Caucasians.
Statistical Information
Confidence Interval
95%CI, 1.19–1.65 for GSTM1; 95%CI, 1.05–1.62 for GSTT1
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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