Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization
2001
Identifying Genes Linked to Kidney Cancer
Sample size: 11
publication
Author Information
Author(s): Stassar M J J G, Devitt G, Brosius M, Rinnab L, Prang J, Schradin T, Simon J, Petersen S, Kopp-Schneider A, Zöller M
Primary Institution: German Cancer Research Center
Hypothesis
The study aims to identify biological features of renal cell carcinoma (RCC) that could serve as alternative therapeutic targets.
Conclusion
The study identified 14 differentially expressed genes in renal cell carcinoma that may be potential therapeutic targets.
Supporting Evidence
- 11 genes were strongly up-regulated or selectively expressed in more than one RCC tissue or cell line.
- 3 of the identified genes were confirmed to be overexpressed through screening.
- Only 6 of the 14 differentially expressed genes have been previously associated with RCC.
Takeaway
Researchers looked at kidney cancer cells to find special genes that could help in treating the disease better.
Methodology
Suppression subtractive hybridization was performed on patient-matched normal renal and RCC tissue.
Participant Demographics
Human renal cell carcinoma patients.
Digital Object Identifier (DOI)
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