CREB Is Activated by Muscle Injury and Promotes Muscle Regeneration
2011
CREB Activation and Muscle Regeneration
Sample size: 6
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Stewart Randi, Flechner Lawrence, Montminy Marc, Berdeaux Rebecca
Primary Institution: University of Texas Health Science Center at Houston
Hypothesis
CREB activation contributes to muscle regeneration after injury.
Conclusion
Activated CREB promotes myoblast proliferation and enhances muscle regeneration in mice.
Supporting Evidence
- CREB phosphorylation is induced after acute muscle injury.
- Activated CREB promotes myoblast proliferation in vitro.
- Genetic activation of CREB enhances muscle regeneration in dystrophic mice.
Takeaway
When muscles get hurt, a protein called CREB helps the muscle cells grow and heal faster.
Methodology
The study used mouse models and primary myoblast cultures to investigate the role of CREB in muscle regeneration.
Participant Demographics
Mice, including wild-type and genetically modified strains.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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