Genetic Factors in Ulcerative Colitis Risk and Severity
Author Information
Author(s): Chen Min, Peyrin-Biroulet Laurent, Xia Bing, Guéant-Rodriguez Rosa-Maria, Bronowicki Jean-Pierre, Bigard Marc-André, Guéant Jean-Louis
Primary Institution: Inserm, U724, Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine, Nancy-Université, Nancy- Vandoeuvre, France
Hypothesis
The study evaluates the association of genetic polymorphisms related to homocysteine metabolism with ulcerative colitis in Central China.
Conclusion
Methionine synthase and methylenetetrahydrofolate reductase are associated with the risk and extent of ulcerative colitis in Central China.
Supporting Evidence
- The frequency of the methionine synthase 2756G allele was higher in ulcerative colitis patients compared to controls.
- The methylenetetrahydrofolate reductase 677TT genotype was more prevalent in individuals with pancolitis.
- Carriage of the 677TT or 677CT/1298AC genotypes was more frequent in cases with pancolitis.
Takeaway
Some genes can make people more likely to get a disease called ulcerative colitis, which affects the intestines.
Methodology
168 patients with ulcerative colitis were genotyped and compared to 219 matched controls.
Limitations
The study was limited to a specific population in Central China, which may affect the generalizability of the findings.
Participant Demographics
All participants were Han ethnicity from Hubei province, China.
Statistical Information
P-Value
P = 0.0137
Confidence Interval
95% C.I. 0.11–0.19
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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