Comparing Brain Blood Flow Measurement Techniques in Pigs
Author Information
Author(s): Bein Berthold, Meybohm Patrick, Cavus Erol, Tonner Peter H, Steinfath Markus, Scholz Jens, Doerges Volker
Primary Institution: University Hospital Schleswig-Holstein, Campus Kiel, Germany
Hypothesis
The study aims to compare cerebral hemodynamics assessed using the blood flow index (BFI) derived from indocyanine green (ICG) with transcranial Doppler ultrasound (TCD) during hemorrhagic shock.
Conclusion
Both FVmean and BFI effectively reflected changes in cerebral perfusion during hemorrhage and after resuscitation, showing significant correlation.
Supporting Evidence
- BFI and FVmean were significantly correlated (r = 0.62, p < 0.0001).
- Cerebral perfusion pressure (CPP) dropped significantly during hemodynamic decompensation.
- BFI and FVmean increased close to baseline values after resuscitation.
Takeaway
The study tested two ways to measure blood flow in the brain of pigs during a medical emergency, finding that both methods worked well together.
Methodology
20 healthy pigs underwent simulated liver trauma, followed by monitoring of cerebral blood flow using ICG and TCD.
Potential Biases
Potential bias due to the use of different drugs for resuscitation which may affect cerebral blood flow.
Limitations
ICG measurements require specific training, and the path length of NIRS in pigs is unknown.
Participant Demographics
Healthy pigs aged 12 to 16 weeks, weighing 43 to 48 kg.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% confidence interval 0.89 to 0.98
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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