I-TASSER server for protein 3D structure prediction
2008
I-TASSER Server for Protein Structure Prediction
Sample size: 800
publication
Evidence: high
Author Information
Author(s): Zhang Yang
Primary Institution: University of Kansas
Hypothesis
The I-TASSER server can provide accurate 3D protein structure predictions from amino acid sequences.
Conclusion
The I-TASSER server generates reliable 3D protein structure predictions and provides users with quantitative assessments of model quality.
Supporting Evidence
- I-TASSER was ranked as the best method in the server section of the recent 7th CASP experiment.
- A strong correlation (0.91) was found between the C-score and TM-score of the predicted models.
- The I-TASSER server has generated structure predictions for thousands of modeling requests from over 35 countries.
Takeaway
The I-TASSER server helps scientists predict how proteins look in 3D using just their amino acid sequences, making it easier for everyone to study proteins.
Methodology
The I-TASSER server uses a hierarchical modeling approach and a confidence scoring system to predict protein structures.
Limitations
The server's accuracy may vary for multiple-domain proteins and lower-ranked models.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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