Treatment Outcome and Mortality in HIV Infected TB Patients in South India
Author Information
Author(s): Vijay Sophia, Kumar Prahlad, Chauhan Lakbir Singh, Narayan Rao Saroja Vadigepalli, Vaidyanathan Preetish
Primary Institution: National Tuberculosis Institute, Bangalore, India
Hypothesis
What is the impact of HIV-related immunosuppression on TB treatment outcomes and mortality among HIV infected TB patients?
Conclusion
Despite a treatment success rate of 75%, the high mortality rate of 30% among HIV infected TB patients is concerning and requires immediate intervention.
Supporting Evidence
- 75% of HIV infected TB patients achieved treatment success.
- 30% of the patients in the study group were reported dead.
- Non initiation of ART was significantly associated with unfavourable treatment outcomes.
- Pulmonary TB was identified as a risk factor for unfavourable outcomes.
Takeaway
This study looked at how well HIV infected people with tuberculosis (TB) did with their treatment and how many died afterward. Even though most got better, a lot still died, which is a big problem.
Methodology
The study followed 281 HIV infected TB patients treated with intermittent short course chemotherapy and assessed treatment outcomes and mortality through patient interviews and program records.
Potential Biases
The study was retrospective and based on program records, which may introduce reporting biases.
Limitations
Some important factors like clinical manifestations and drug susceptibility status could not be studied, and CD4 counts were missing for a significant number of patients.
Participant Demographics
{"age_distribution":{"<15":3,"15-44":143,"45-64":29,"65+":1},"gender":{"male":125,"female":51},"marital_status":{"married":143,"unmarried":33},"literacy":{"literate":106,"illiterate":70},"employment_status":{"employed":105,"unemployed":51}}
Statistical Information
P-Value
p<0.05
Confidence Interval
{"treatment_outcome":"(1.02–3.77)","mortality":"(1.15–6.81)"}
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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