Chemical Composition, Free Radicals and Pathogenic Microbes in the Extract Derived from Dictyota dichotoma: In Silico and In Vitro Approaches
2024

Exploring the Health Benefits of Dictyota dichotoma Extract

publication 10 minutes Evidence: moderate

Author Information

Author(s): Oumassi Fouad, Chebbac Khalid, Ben Ali Naouar, Kaabi Soundouss, El Ansari Zineb Nejjar, Metouekel Amira, El Barnossi Azeddin, El Moussaoui Abdelfattah, Chebaibi Mohamed, Bounab Loubna, Mssillou Ibrahim, Shahat Abdelaaty Abdelaziz, L’bachir El Kbiach Mohammed, Li Xiaohui, Wei Yingze, Fan Jianhua

Primary Institution: King Saud University

Hypothesis

The study aims to evaluate the antioxidant and antimicrobial properties of the extract derived from Dictyota dichotoma.

Conclusion

The extract of Dictyota dichotoma shows significant antioxidant and antimicrobial properties due to its rich content of bioactive compounds.

Supporting Evidence

  • The ethanolic extract of Dictyota dichotoma is rich in phenolic compounds, with 22 phycocompounds identified.
  • The antioxidant activity showed an IC50 of 120 µg/mL for the DPPH assay.
  • The extract demonstrated significant antibacterial activity against various strains, including E. coli and S. aureus.
  • In silico studies identified key compounds with high docking scores against relevant enzymes.
  • The total antioxidant capacity of the extract was measured at 685.26 µg AAE/mg.

Takeaway

This study found that a type of seaweed called Dictyota dichotoma can help fight germs and is good for health because it has special natural ingredients.

Methodology

The study used liquid chromatography–mass spectrometry (HPLC-MS) for phytochemical characterization and conducted in vitro tests to assess antioxidant and antimicrobial activities.

Digital Object Identifier (DOI)

10.3390/md22120565

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