(2E,25E)-11,14,17,33,36,39,42-Heptaoxapentacyclo[41.4.0.05,10.018,23.027,32]heptatetraconta-1(43),2,5(10),6,8,18,20,22,25,27,29,31,44,46-tetradecaene-4,24-dione C40H40O9
2011
Synthesis and Structure of a Macrocyclic Compound
publication
Evidence: moderate
Author Information
Author(s): Anh Le Tuan, Hieu Truong Hong, Soldatenkov Anatoly T., Soldatova Svetlana A., Khrustalev Victor N.
Primary Institution: Vietnam National University
Hypothesis
The study investigates the synthesis of a ditopic ligand with two azacrown units connected by a polyether chain.
Conclusion
The synthesized compound adopts a saddle-like conformation and includes a 31-crown-7-ether skeletal unit.
Supporting Evidence
- The compound was synthesized through a modified Petrenko–Kritchenko reaction.
- The internal cavity of the macrocycle is approximately 125 Å3.
- The two ethylene fragments in the compound have E configurations.
Takeaway
The researchers made a new chemical compound that has a special shape and can hold other molecules inside it.
Methodology
The synthesis involved a domino reaction of three components: dialkyl ketone, bis(2-formylphenoxy)-3-oxapentane, and ammonium acetate.
Digital Object Identifier (DOI)
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