FGFR3 Gene is Conserved in Dogs of Different Sizes
Author Information
Author(s): Logan B Smith, Danika L Bannasch, Amy E Young, Deborah I Grossman, Janelle M Belanger, Anita M Oberbauer
Primary Institution: University of California, Davis
Hypothesis
Could sequence differences in FGFR3 account for size differences in dogs?
Conclusion
The FGFR3 gene is conserved across dog breeds, suggesting that other genes are responsible for size variability.
Supporting Evidence
- FGFR3 gene sequence was fully conserved across all breeds studied.
- Sequence variation was only found in intronic regions, not in the coding regions.
- Other genes likely account for the skeletal size differences in dogs.
Takeaway
The FGFR3 gene, which helps control bone growth, is the same in all dog breeds studied, meaning other genes must be responsible for their size differences.
Methodology
Sequenced all exons, the promoter region, and 60 bp of the 3' flanking region of the FGFR3 gene in nine dog breeds.
Limitations
Only a limited number of breeds were studied, and the focus was on specific regions of the FGFR3 gene.
Participant Demographics
Nine different dog breeds representing a spectrum of skeletal size.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website