Monitoring Photodynamic Therapy with Scintigraphy
Author Information
Author(s): R.B. Moore, J.D. Chapman, A.D. Mokrzanowski, M.R. Arnfield, M.S. McPhee, A.J. McEwan
Primary Institution: Cross Cancer Institute, University of Alberta
Hypothesis
Can non-invasive scintigraphy effectively monitor the vascular shut-down induced by photodynamic therapy in different types of Dunning prostatic tumors?
Conclusion
The study demonstrated that photodynamic therapy induces a light-dose-dependent and time-dependent vascular shut-down in both well-differentiated and anaplastic Dunning prostatic tumors.
Supporting Evidence
- Maximal vascular shut-down occurred about 8 hours post-PDT after a 1,600J light dose.
- Well differentiated tumors were found to be 1.77 times better perfused than anaplastic tumors.
- Perfusion shut-down was significantly greater when light exposure occurred 2 hours after photosensitizer administration compared to 24 hours.
Takeaway
This study shows that a special imaging technique can help doctors see how well a light treatment works on tumors by checking blood flow.
Methodology
Rats with Dunning prostatic tumors were treated with photodynamic therapy and monitored using 99mTc-HMPAO scintigraphy to assess changes in tumor perfusion.
Limitations
The study was conducted in a rat model, which may not fully represent human tumors.
Participant Demographics
Rats (Copenhagen x Fischer, F1 hybrids) were used in the study.
Statistical Information
P-Value
0.02
Statistical Significance
p<0.05
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