Early Chemotherapy After Surgery for Advanced Gastric Cancer
Author Information
Author(s): Y. Maehara, K. Sugimachi, M. Akagi, T. Kakegawa, H. Shimazu, M. Tomita
Primary Institution: Kyushu University, Fukuoka, Japan
Hypothesis
Does early postoperative chemotherapy improve survival rates in patients with advanced gastric cancer following noncurative resection?
Conclusion
Early postoperative chemotherapy with 5-FU improved the survival rate in patients with advanced gastric cancer, although not statistically significant.
Supporting Evidence
- 162 patients were eligible for statistical assessment.
- The 1-year survival rate was 35.5% for group A and 49.0% for group B.
- The 50% survival rate was 8.9 months for group A and 12.9 months for group B.
- Patients in group B received additional 5-FU injections.
Takeaway
Doctors tested if giving chemotherapy right after surgery helps people with stomach cancer live longer. They found it might help a little bit.
Methodology
The study was a prospective randomized controlled trial involving 186 patients who underwent noncurative gastric resection.
Limitations
The study had a small sample size and the statistical significance was not achieved.
Participant Demographics
Patients were aged less than 76 years with a performance status grade of 0-3.
Statistical Information
P-Value
0.169
Statistical Significance
p=0.169
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