The Role of Ectopic Fat in Metabolic Syndrome
Author Information
Author(s): Janssen Joseph A. M. J. L.
Primary Institution: Erasmus Medical Center
Hypothesis
Ectopic fat deposition plays a causal role in the pathogenesis of metabolic syndrome.
Conclusion
Preventing ectopic fat deposition may reduce the risk of metabolic syndrome and its effects.
Supporting Evidence
- Ectopic fat deposition is linked to insulin resistance and metabolic syndrome.
- Hyperinsulinemia can precede insulin resistance in healthy individuals.
- Marked reductions in ectopic fat can reverse insulin resistance.
Takeaway
Eating too much and not being active can cause fat to build up in the wrong places in our bodies, which can make us sick. If we can stop this fat from building up, we can help keep people healthy.
Methodology
This review discusses the relationship between overnutrition, hyperinsulinemia, ectopic fat deposition, and insulin resistance in the development of metabolic syndrome.
Limitations
The studies discussed are mostly observational and cannot definitively establish causation.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website