Mast Cell Count in Oral Dysplasia and Cancer
Author Information
Author(s): Atarbashi-Moghadam Saede, Niazmand Maral, Vafadar Shahla, Gholami Toghchi Sanaz
Primary Institution: Shahid Beheshti University of Medical Sciences
Hypothesis
This research aimed to assess the number of mast cells in oral SCC and dysplastic leukoplakia and explore their possible role in these lesions.
Conclusion
The mast cell count was higher in epithelial dysplasia compared to oral squamous cell carcinoma, suggesting an increase in these cells during the pre-malignant stages.
Supporting Evidence
- The mast cell count was significantly lower in SCC compared to ED (p= 0.009).
- There was no correlation between mast cell count and inflammation score (p= 0.345).
- The mean age of participants was 56.34 years.
Takeaway
The study found that there are more mast cells in early stages of oral lesions, but their numbers drop when cancer develops.
Methodology
This was a retrospective cross-sectional study examining 63 archival cases using toluidine blue staining to count mast cells.
Participant Demographics
54.9% male and 45.1% female, mean age 56.34 years.
Statistical Information
P-Value
0.009
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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