Sex-Specific Changes in Lipids as Mice Age
Author Information
Author(s): Xu Ziying, Bhattacharjee Anindita, Han Xianlin
Primary Institution: Barshop Institute, San Antonio, Texas, United States
Hypothesis
The study investigates how aging affects the lipid profiles in male and female mice differently.
Conclusion
The study found that male mice show significant changes in their lipid profiles as they age, while female mice maintain a consistent lipid profile throughout their lifespan.
Supporting Evidence
- Males showed higher concentrations of nearly all lipid classes at each age compared to females.
- Males exhibited a decline in major phospholipids and an accumulation of cholesteryl ester with age.
- An increase in phosphatidylserine, linked to apoptotic signaling, was exclusive to males.
- Females maintained a consistent plasma lipid profile throughout their lifespan.
- Both sexes experienced a decrease in plasmalogen with age, suggesting increasing oxidative stress.
Takeaway
As mice get older, the fats in their bodies change differently for boys and girls, with boys showing more changes than girls.
Methodology
The study used multi-dimensional mass spectrometry-based shotgun lipidomics to analyze plasma lipidome alterations in C57BL/6 mice across different ages.
Participant Demographics
C57BL/6 mice, both male and female, aged 8 to 32 months.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website