Encephalopathy Mimicking Atypical Parkinsonism
Author Information
Author(s): Schirò Giuseppe, Gastaldi Matteo, Iacono Salvatore, Scaranzin Silvia, Picciolo Valentina, Arnao Valentina, Ferrari Anita, Gagliardo Cesare, D’Amelio Marco
Primary Institution: Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo
Hypothesis
Can paraneoplastic neurological syndromes (PNSs) with dual positivity for anti-GAD65 and anti-CRMP5/CV2 antibodies present as atypical parkinsonism?
Conclusion
The study suggests that PNS should be considered as a potential diagnosis for parkinsonism, especially when accompanied by cognitive decline or ataxia.
Supporting Evidence
- A 68-year-old man presented with cognitive decline and parkinsonism.
- The patient tested positive for anti-GAD65 and anti-CRMP5/CV2 antibodies.
- A microcitoma was found in the lung during investigations.
- Previous literature indicates that PNS can mimic degenerative parkinsonism.
Takeaway
This study talks about a 68-year-old man who had symptoms like shaking and memory problems, which turned out to be caused by a rare condition related to cancer, not just old age.
Methodology
The study involved a case report and a review of literature on PNS cases with parkinsonism associated with anti-GAD65 and anti-CRMP5/CV2 antibodies.
Limitations
The study is based on a single case report, which may limit the generalizability of the findings.
Participant Demographics
68-year-old Caucasian male.
Digital Object Identifier (DOI)
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