Suppression of Cellular Transformation by Poly (A) Binding Protein Interacting Protein 2 (Paip2) A Novel Tumor Suppressor, Paip2
2011
Paip2: A New Tumor Suppressor
publication
Evidence: moderate
Author Information
Author(s): Amy B. Rosenfeld
Primary Institution: Columbia University College of Physicians & Surgeons
Hypothesis
Can Paip2 function as a tumor suppressor by inhibiting cellular transformation?
Conclusion
Paip2 acts as a tumor suppressor by inhibiting the transformation of cells mediated by the oncogene hRasV12.
Supporting Evidence
- Increased levels of Paip2 reduced colony formation in a semi-solid matrix.
- Paip2 delayed the G1/S transition in NIH3T3 cells.
- Paip2's ability to bind to Pabp is necessary for its tumor suppressor function.
Takeaway
Paip2 is a protein that helps keep cells from growing uncontrollably, which can lead to cancer.
Methodology
The study involved overproducing Paip2 in NIH3T3 cells and analyzing its effects on cell growth and transformation.
Digital Object Identifier (DOI)
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