Registry for Late Effects after Childhood Radiotherapy
Author Information
Author(s): Bolling Tobias, Schuck Andreas, Pape Hildegard, Rube Christian, Pollinger Barbara, Timmermann Beate, Kortmann Rolf D, Dieckmann Karin, Willich Normann
Primary Institution: Department of Radiotherapy, University Hospital of Münster, Germany
Hypothesis
The study aims to evaluate radiation dose-effect relationships in organs and part of organs with special regard to late side effects.
Conclusion
The RiSK registry is the only multi-centre study that evaluates radiation-associated side effects prospectively with detailed information about organ dose levels.
Supporting Evidence
- The study started in a pilot phase in June 2001 and has been ongoing since 2004.
- Documentation is planned for all children receiving radiotherapy in therapy trials of the GPOH.
- The documentation forms are available in both English and German.
Takeaway
This study is like a big notebook where doctors write down how kids react to radiation treatment, so they can learn more about the good and bad effects later on.
Methodology
Radiation parameters including detailed organ doses and toxicity evaluations are collected prospectively from centers across Germany using standardized documentation forms.
Limitations
Retrospective analyses can only be performed with uncertain estimations of the radiation doses at special organs due to lack of detailed organ dose evaluation.
Digital Object Identifier (DOI)
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