NPC 15669 Reduces Lung Injury During Heart Surgery in Pigs
Author Information
Author(s): J. M. Bator, A. M. Gillinov, K. J. Zehr, J. M. Redmond, I. C. Wilson, A. Herskowitz, J. R. Connor, R. M. Burch, D. E. Cameron
Primary Institution: Johns Hopkins Medical Institution
Hypothesis
Can NPC 15669 inhibit neutrophil activation and tissue injury during cardiopulmonary bypass in pigs?
Conclusion
NPC 15669 effectively inhibits neutrophil activation and reduces lung injury during cardiopulmonary bypass.
Supporting Evidence
- NPC 15669 significantly inhibited the increase in CD18 expression during CPB.
- Lung tissue myeloperoxidase content was significantly lower in treated pigs.
- Histological evaluation showed less neutrophil infiltration in treated animals.
- Percentage wet weight of lung tissue was significantly lower in treated pigs.
Takeaway
This study shows that a drug called NPC 15669 can help protect pig lungs from damage during heart surgery by stopping certain white blood cells from causing harm.
Methodology
Pigs were treated with NPC 15669 during cardiopulmonary bypass, and various measures of lung injury and neutrophil activation were assessed.
Participant Demographics
Piglets weighing 10-12 kg
Statistical Information
P-Value
p<0.0004
Statistical Significance
p<0.05
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