HPV Vaccine Response in People Living with HIV
Author Information
Author(s): Akumbom Alvine M., Bergman Alanna J., Strickler Howard, Budhathoki Chakra, Nkimbeng Manka, Grant Raeven, Reynolds Nancy R., Talaat Kawsar R.
Primary Institution: Johns Hopkins University
Hypothesis
How does the HPV vaccine efficacy differ in people living with HIV compared to those without?
Conclusion
The study found that HPV vaccine efficacy is lower in people living with HIV, with significant differences in immune response compared to those without HIV.
Supporting Evidence
- HPV vaccine efficacy is lower in people living with HIV compared to those without.
- Significant differences in immune response were observed between the two groups.
- Risk factors for lower vaccine efficacy include CD4+ T-cell count and HIV viral load.
- Booster doses may improve vaccine response in people living with HIV.
Takeaway
This study looks at how well the HPV vaccine works for people with HIV and finds that it doesn't work as well for them as it does for people without HIV.
Methodology
A systematic review and meta-analysis of HPV vaccine trials in people living with HIV, following PRISMA guidelines.
Potential Biases
Potential bias due to the variability in eligibility criteria across studies.
Limitations
Only studies published in English were included, which may limit the generalizability of the findings.
Participant Demographics
The studies included participants from various countries, with a mix of genders and ages, primarily focusing on those living with HIV.
Statistical Information
P-Value
-0.434 for HPV16 and -0.57 for HPV18
Confidence Interval
95% CI: -0.823, -0.046 for HPV16; 95% CI: -0.72, -0.43 for HPV18
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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