Overexpression of Bcl-2 enhances metastatic potential of human bladder cancer cells
1999
Bcl-2 and Bladder Cancer Metastasis
publication
Evidence: moderate
Author Information
Author(s): Miyake H, Hara I, Yamanaka K, Gohji K, Arakawa S, Kamidono S
Primary Institution: Kobe University School of Medicine
Hypothesis
Does overexpression of Bcl-2 enhance the metastatic potential of bladder cancer cells?
Conclusion
Overexpression of Bcl-2 in bladder cancer cells leads to increased metastatic potential.
Supporting Evidence
- Bcl-2-transfected cells formed more than three times as many tumor nodules in the lungs compared to control cells.
- Tumor progression was more advanced in Bcl-2 overexpressing cells than in control cells.
Takeaway
When bladder cancer cells have more Bcl-2, they can survive better and spread more easily in the body.
Methodology
The study used Bcl-2-transfected bladder cancer cell lines and injected them into athymic nude mice to observe tumor formation and progression.
Digital Object Identifier (DOI)
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