Using Extracorporeal Lung Assist with High-Frequency Ventilation in Pigs
Author Information
Author(s): Ralf M Muellenbach, Julian Kuestermann, Markus Kredel, Amélie Johannes, Ulrike Wolfsteiner, Frank Schuster, Christian Wunder, Peter Kranke, Norbert Roewer, Jörg Brederlau
Primary Institution: University of Wuerzburg, Department of Anaesthesiology
Hypothesis
The application of high oscillatory frequencies requires the combination of HFOV with arteriovenous extracorporeal lung assist (av-ECLA) to maintain or reestablish normocapnia in a model of acute respiratory distress (ARDS).
Conclusion
The combination of high-frequency oscillatory ventilation and av-ECLA can maintain normocapnia even at high oscillatory frequencies.
Supporting Evidence
- Lung recruitment and adjusting the mean airway pressure resulted in significant improvement of oxygenation.
- Oxygenation remained significantly improved with rising frequencies.
- Normocapnia during HFOV was maintained with av-ECLA at frequencies of 9 Hz and above.
Takeaway
In this study, pigs with lung problems were helped by a special machine that assisted their breathing, allowing them to breathe better even when using fast breathing techniques.
Methodology
Eight female pigs were used in a model of ARDS, where they were ventilated with oscillatory frequencies ranging from 3–15 Hz, and measurements were taken with and without av-ECLA.
Limitations
The study used a surfactant-depletion model of ARDS, which may not fully represent adult ARDS mechanisms.
Participant Demographics
Eight healthy female pigs, average weight 56.5 kg.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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