Trends in Antimicrobial Resistance in a Greek Hospital
Author Information
Author(s): Matthew E. Falagas, Sofia K. Kasiakou, Dimitra Nikita, Panayiota Morfou, George Georgoulias, Petros I. Rafailidis
Primary Institution: Henry Dunant Hospital, Athens, Greece
Hypothesis
What are the secular trends of antimicrobial resistance of blood isolates in a newly founded Greek hospital?
Conclusion
There has been an alarming increase in antimicrobial resistance of Acinetobacter baumannii isolates during the study.
Supporting Evidence
- Acinetobacter baumannii showed increased resistance to amikacin, ciprofloxacin, imipenem, and piperacillin/tazobactam.
- The frequency of blood isolates did not differ significantly from older hospitals.
- Gram-positive bacteria were more common than Gram-negative bacteria throughout the study period.
Takeaway
The study looked at how germs in a new hospital in Greece are becoming resistant to medicines over time, especially a type of germ called Acinetobacter baumannii.
Methodology
The study evaluated blood isolates and their antimicrobial susceptibility patterns over a period of four and a half years.
Potential Biases
Some isolates with antimicrobial resistance may be clonally related due to lack of molecular typing.
Limitations
The study did not perform molecular typing to identify epidemic clones and did not interpret results in terms of culture contamination.
Participant Demographics
Patients admitted to Henry Dunant Hospital, Athens, Greece.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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