1-(1-Hydroxyethyl)-7,8-dihydroindolo[2,3-a]pyridine[3,4-g]quinolizin-5(13H)-one (angustoline) monohydrate from Nauclea subdita (Rubiaceae)
2011
Study of angustoline monohydrate from Nauclea subdita
publication
Evidence: moderate
Author Information
Author(s): Liew Sook Yee, Mukhtar Mat Ropi, Awang Khalijah, Mustafa Mohd Rais, Ng Seik Weng
Primary Institution: University of Malaya
Conclusion
The study successfully isolated and characterized angustoline monohydrate, revealing its unique crystal structure and hydrogen bonding interactions.
Supporting Evidence
- The compound angustoline was isolated as a monohydrate.
- The crystal structure revealed a fused-ring system with specific dihedral angles.
- Hydrogen bonding was observed between the amino and hydroxy groups and the water molecule.
Takeaway
Researchers found a special compound called angustoline in a plant, and they figured out how its molecules are arranged in a crystal.
Methodology
The compound was extracted from Nauclea subdita using hexane and dichloromethane, followed by purification through column chromatography.
Digital Object Identifier (DOI)
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