Insulin Resistance and Bone Mineral Density: A Systematic Review
Author Information
Author(s): Shirinezhad Amirhossein, Azarboo Alireza, Ghaseminejad-Raeini Amirhossein, Kanaani Nejad Fatemeh, Zareshahi Negar, Amiri Sheyda Mohtasham, Tahmasebi Yasamin, Hoveidaei Amir Human
Primary Institution: Tehran University of Medical Sciences
Hypothesis
What is the association between insulin resistance surrogate indices and bone mineral density?
Conclusion
The review suggests that while the HOMA index shows no association with bone mineral density, higher TyG indices are generally linked to lower bone mineral density.
Supporting Evidence
- The systematic review included 27 studies.
- 71,525 participants were analyzed.
- Most studies indicated no association between HOMA-IR and BMD.
- Higher TyG index is generally associated with lower BMD.
- Other indices like VAI and METS-IR showed positive associations with BMD.
Takeaway
This study looked at how insulin resistance affects bone health. It found that some measures of insulin resistance might be linked to lower bone strength.
Methodology
A systematic review of observational studies was conducted, analyzing data from various databases.
Potential Biases
Variability in covariates adjusted for in different studies may introduce bias.
Limitations
The study's limitations include the inability to perform a meta-analysis and the reliance on cross-sectional studies, which limits causal inferences.
Participant Demographics
The review included 71,525 participants, with 52.1% being female and a mean age ranging from 30.3 to 73.6 years.
Digital Object Identifier (DOI)
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