Binding of Magnesium and Manganese to Uridine Phosphates
Author Information
Author(s): Zea Corbin, Camci-Unal Gulden, Pohl Nicola L
Primary Institution: Iowa State University
Hypothesis
The study investigates the binding relationship between divalent metals magnesium and manganese and uridine phosphates to understand their role in carbohydrate biosynthesis.
Conclusion
The binding strength of divalent metal cations magnesium and manganese to uridine phosphates is influenced by the formal charge state of the phosphate-containing substrates.
Supporting Evidence
- Magnesium and manganese showed similar trends in binding to sugar substrates.
- Binding parameters were determined for Mg+2 and Mn+2 to various uridine phosphates.
- The binding strength decreases as phosphates are removed from the substrates.
Takeaway
Magnesium and manganese help in the process of making sugars in our body, and how well they stick to certain molecules can change how our body uses those sugars.
Methodology
Isothermal titration calorimetry was used to study the binding of magnesium and manganese to various uridine phosphates.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website