Expression of hMLH1 is inactivated in the gastric adenomas with enhanced microsatellite instability
2001
Inactivation of hMLH1 in Gastric Adenomas
Sample size: 86
publication
Evidence: moderate
Author Information
Author(s): Baek M J, Kang H, Kim S E, Park J H, Lee J S, Paik Y-K, Kim H
Primary Institution: Yonsei University College of Medicine
Hypothesis
What is the role of hMLH1 and hMSH2 in gastric adenomas with microsatellite instability?
Conclusion
The inactivation of hMLH1 gene expression by promoter methylation is an early event and may be the origin of microsatellite instability in gastric adenomas.
Supporting Evidence
- MSI was found in 15 (17%) of gastric adenomas.
- Absent or decreased hMLH1 expression was noted in most of the MSI-positive adenomas (87%).
- All MSI-positive tumours showed methylation of the hMLH1 gene promoter.
- Rare inactivation of hMLH1 expression was found in MSI-negative adenomas (4%).
- Intense expression of hMSH2 was observed in most gastric adenomas regardless of MSI status.
Takeaway
Some stomach growths called adenomas can have problems with their genes, and this study found that a specific gene, hMLH1, is often turned off in those growths.
Methodology
Expressions of hMLH1 and hMSH2 were explored in gastric adenomas and compared with gastric carcinomas.
Digital Object Identifier (DOI)
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