Sialyl Lewis x in Canine Mammary Tumours
Author Information
Author(s): Pinho Salomé S, Matos Augusto JF, Lopes Célia, Marcos Nuno T, Carvalheira Júlio, Reis Celso A, Gärtner Fátima
Primary Institution: Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)
Hypothesis
Does the expression of Sialyl Lewis x correlate with E-Cadherin expression and clinicopathological features in canine malignant mammary tumours?
Conclusion
Sialyl Lewis x is important in the malignant phenotype of canine mammary tumours and is inversely correlated with E-Cadherin expression.
Supporting Evidence
- All 53 cases of canine mammary carcinomas expressed Sialyl Lewis x.
- Higher Sialyl Lewis x expression was associated with lymph node metastases.
- Sialyl Lewis x and E-Cadherin expression were inversely correlated.
Takeaway
This study found that a specific marker, Sialyl Lewis x, is linked to cancer in dogs and can help predict how aggressive the cancer is.
Methodology
Immunohistochemical analysis of 53 canine mammary carcinoma cases using monoclonal antibodies against Sialyl Lewis x and E-Cadherin.
Potential Biases
Potential observer bias in scoring immunohistochemical staining.
Limitations
The study's findings may not be generalizable due to the specific population of dogs studied.
Participant Demographics
35 female dogs aged 3 to 16 years, various breeds.
Statistical Information
P-Value
0.034
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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