Histological and radiographic assessment of the regenerative potential of sodium hexametaphosphate (SHMP) as a novel direct pulp capping material in an animal model
2025

Assessing Sodium Hexametaphosphate for Pulp Capping in Dogs

Sample size: 3 publication Evidence: moderate

Author Information

Author(s): Mohamed Mostafa Kamel, Abdelrahman Mohamed Abdelfattah, Abdel-Razik Abdel-Razik Hashem, Elheeny Ahmad Abdel Hamid

Primary Institution: Minia University

Hypothesis

The study aimed to evaluate the histological and radiographic effects of sodium hexametaphosphate (SHMP) as a direct pulp capping agent compared to mineral trioxide aggregate (MTA).

Conclusion

SHMP showed better bioinductive and biocompatible properties than MTA, particularly in promoting root length increase.

Supporting Evidence

  • SHMP resulted in a higher average thickness of predentin and odontoblastic layers compared to MTA.
  • 100% of SHMP specimens showed fully calcified dentin bridges, while only 66.7% of MTA specimens did.
  • SHMP specimens had significantly more regularly arranged dentinal tubules than MTA specimens.

Takeaway

This study tested a new material called SHMP for treating teeth in dogs, and it worked better than the traditional material.

Methodology

A split-mouth design was used with three healthy 4-month-old Mongrel dogs, each having 36 premolars treated with either SHMP or MTA.

Limitations

The study was conducted in an ideal environment with healthy teeth and may not reflect responses in teeth with pre-existing inflammation.

Participant Demographics

Three healthy 4-month-old Mongrel dogs, two males and one female.

Statistical Information

P-Value

p<0.0001

Confidence Interval

95% CI of 0.13; 0.72

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/s12903-024-05297-0

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