Traditional Herbal Medicine Rikkunshito Protects Small Intestinal Cells
Author Information
Author(s): Tamaki Kumiko, Otaka Michiro, Shibuya Tomoyoshi, Sakamoto Naoto, Yamamoto Soh, Odashima Masaru, Itoh Hideaki, Watanabe Sumio
Primary Institution: Juntendo University School of Medicine
Hypothesis
Does Rikkunshito (TJ-43) enhance the expression of HSP60 and cytoprotection in small intestinal epithelial cells?
Conclusion
Rikkunshito significantly induces HSP60 and enhances the cytoprotective ability of small intestinal epithelial cells against damage.
Supporting Evidence
- HSP60 was significantly induced by TJ-43.
- Cell necrosis and apoptosis were significantly suppressed in IEC-6 cells pretreated by TJ-43.
- Hydrogen peroxide-induced cell necrosis was significantly suppressed in IEC-6 cells pretreated with TJ-43.
Takeaway
Rikkunshito is a herbal medicine that helps protect the cells in your intestines from getting hurt by certain medicines.
Methodology
The study evaluated the effect of Rikkunshito on HSP60 expression and cytoprotective abilities in IEC-6 cells using immunoblot analysis and various assays.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website