Effects of Anaesthetics and L-Carnitine on TNF Production in Surgical Patients
Author Information
Author(s): Giovanna Delogu, Claudio De Simone, Giuseppe Famularo, Alessandra Fegiz, Francesca Paoletti, Emilio Jirillo
Primary Institution: University 'La Sapienza' Rome
Hypothesis
Anaesthetics and L-carnitine affect the production of tumour necrosis factor (TNF) in surgical patients.
Conclusion
L-carnitine administration significantly reduced TNF levels in surgical patients compared to those who did not receive it.
Supporting Evidence
- Pentothal significantly increased TNF production in vitro compared to LPS.
- L-carnitine administration resulted in a strong reduction of TNF levels post-surgery.
- Patients receiving L-carnitine had lower TNF levels at multiple time points compared to the control group.
Takeaway
This study found that L-carnitine can help lower a harmful substance in the body after surgery, which might help patients feel better.
Methodology
In vitro experiments with PBMCs and in vivo studies with 20 surgical patients receiving either anaesthesia alone or anaesthesia plus L-carnitine.
Potential Biases
Potential bias due to the lack of blinding and randomization in treatment assignment.
Limitations
The study had a small sample size and was limited to specific types of surgery.
Participant Demographics
Patients were well matched for age (average 46 years), weight, and height.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.01
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