Linkage Mapping of Gene Expression Phenotypes
Author Information
Author(s): Bastone Laurel A, Putt Mary E, Ten Have Thomas R, Cheung Vivian G, Spielman Richard S
Primary Institution: University of Pennsylvania School of Medicine
Hypothesis
Can a latent class extension of Haseman-Elston regression effectively account for heterogeneity in linkage mapping of gene expression phenotypes?
Conclusion
The study found that a small number of families contribute to the overall evidence of linkage for gene expression phenotypes.
Supporting Evidence
- All five singleton phenotypes exhibited evidence of a zero slope in one class and a statistically significant negative slope in the other class.
- Families classified as 'linked' had a mean probability of membership in the linked class of 0.988.
- Relatively few families contribute to the overall evidence of linkage despite strong marginal effects.
Takeaway
This study looked at how different families can show different patterns in gene expression, helping scientists understand which families are linked to certain traits.
Methodology
A latent class extension of Haseman-Elston regression was used to analyze expression phenotypes in large pedigrees.
Potential Biases
Potential bias due to the reliance on specific families for linkage evidence.
Limitations
The study's findings may be influenced by the strong dependence on a few families classified as 'linked'.
Participant Demographics
Families from 14 large CEPH pedigrees.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
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