Naringenin's Effect on Constipation in Rats
Author Information
Author(s): Yang Zi-Huan, Yu Hai-Jie, Pan Ao, Du Jian-Yang, Ruan Ye-Chun, Ko Wing-Hung, Chan Hsiao-Chang, Zhou Wen-Liang
Primary Institution: The School of Life Science, Sun Yat-sen University, Guangzhou, China
Hypothesis
Can naringenin effectively promote secretion and alleviate constipation in a rat model?
Conclusion
Naringenin stimulates chloride secretion in the colon and provides a laxative effect in a rat model of constipation.
Supporting Evidence
- Naringenin increased short-circuit current in isolated rat colonic crypts.
- Naringenin restored fecal output and water content in a rat constipation model.
- The effects of naringenin were mediated through cAMP and PKA signaling pathways.
Takeaway
Naringenin, a compound found in citrus fruits, helps the body release more fluids in the intestines, making it easier to go to the bathroom.
Methodology
The study involved isolated rat colonic crypts and a rat constipation model to measure the effects of naringenin on chloride secretion and fecal output.
Limitations
The study was conducted on rats, and results may not directly translate to humans.
Participant Demographics
Male Sprague-Dawley rats, 200-300 g body weight.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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