Creatine and Cyclocreatine in Colon Cancer Treatment
Author Information
Author(s): Kristensen C A, Askenasy N, Jain R K, Koretsky A P
Primary Institution: Massachusetts General Hospital, Harvard Medical School
Hypothesis
The study evaluates the anti-tumour effect of creatine and cyclocreatine in human colon adenocarcinoma.
Conclusion
Creatine and cyclocreatine significantly inhibited tumour growth without causing excessive water accumulation or systemic effects in mice.
Supporting Evidence
- Creatine concentrations of 2.5% and 5% significantly inhibited tumour growth.
- Cyclocreatine at 0.1% and 0.5% also significantly inhibited tumour growth.
- The best correlant of growth inhibition was the total creatine or cyclocreatine concentrations in the tissue.
Takeaway
This study found that two substances, creatine and cyclocreatine, can help slow down the growth of certain cancer cells in mice.
Methodology
Nude mice with human colon adenocarcinoma were fed different concentrations of creatine and cyclocreatine for 2 weeks, and tumour growth was measured.
Limitations
The study was conducted in mice, which may not fully represent human responses.
Participant Demographics
Nude mice carrying human colon adenocarcinoma.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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