Evaluating Edema and Necrosis in Acute Myocarditis
Author Information
Author(s): Marques Joao S, Almeida Ana G, Magalhaes Raquel, Silva Doroteia R, Varela Manuel G, Martins Susana, Brito Dulce A, Diogo Antonio N
Primary Institution: University Hospital Santa Maria, Lisbon, Portugal
Hypothesis
Can serum biomarkers and markers of myocardial necrosis predict edema and necrosis assessed by cardiac magnetic resonance?
Conclusion
In patients with myocarditis, the extent of edema and necrosis evaluated by CMR correlated with the levels of serum biomarkers.
Supporting Evidence
- All patients showed an increase of at least one of the markers of necrosis.
- 100% had elevated troponin levels.
- 93% had increased CRP levels.
- 84% had elevation of NTproBNP.
- The ejection fraction was slightly decreased in 7 patients.
- Oedema and necrosis scores were derived in a segmental basis.
- Significant correlations were found between NTproBNP and WMS, NTproBNP and IN, and troponin and IN.
Takeaway
Doctors looked at patients with heart inflammation to see if blood tests could help predict heart damage seen in special scans.
Methodology
The study included 31 patients diagnosed with acute myocarditis, evaluated using cardiac magnetic resonance and various serum biomarkers.
Participant Demographics
26 males and 5 females, average age 26.3 years.
Statistical Information
P-Value
0.002, 0.02, 0.005, 0.017
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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