Effects of Tocotrienols on Platelet Thrombus Formation in Dogs
Author Information
Author(s): Asaf A Qureshi, Charles W Karpen, Nilofer Qureshi, Christopher J Papasian, David C Morrison, John D Folts
Primary Institution: University of Missouri, Kansas City
Hypothesis
Tocotrienols inhibit platelet aggregation and reduce coronary thrombosis in dogs.
Conclusion
Intravenously administered tocotrienols significantly inhibited platelet aggregation and thrombus formation.
Supporting Evidence
- Tocotrienols reduced collagen-induced platelet aggregation by 59% and TRF by 92%.
- α-Tocopherol treatment resulted in only a 22% decrease in platelet aggregation.
- Tocotrienols abolished cyclic flow reductions in dogs after intravenous administration.
Takeaway
Tocotrienols, a type of vitamin E, can help stop blood clots from forming in dogs, which might help prevent strokes.
Methodology
The study used a canine model with mechanically stenosed coronary arteries to assess the effects of tocotrienols on platelet aggregation.
Limitations
The study was conducted on dogs, and results may not directly translate to humans.
Participant Demographics
Ten anesthetized dogs were used in the study.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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