Hericium erinaceus Extract Reduces Damage in Spinocerebellar Ataxia Models
Author Information
Author(s): Wu Yu-Ling, Sun Hai-Lun, Chang Jui-Chih, Lin Wei-Yong, Chen Pei-Yin, Chen Chin-Chu, Lee Li-Ya, Li Chien-Chun, Hsieh Mingli, Chen Haw-Wen, Yang Ya-Chen, Liu Chin-San, Liu Kai-Li, Napolitano Alessandra, Lavin Martin Francis
Primary Institution: Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan
Hypothesis
Can erinacine A-enriched Hericium erinaceus mycelium ethanol extract improve neuroprotection in models of Spinocerebellar Ataxia Type 3?
Conclusion
The study found that the extract improved longevity and locomotor activity while enhancing antioxidant potency and autophagy in models of Spinocerebellar Ataxia Type 3.
Supporting Evidence
- HEME treatment extended longevity and improved locomotor activity in Drosophila models.
- HEME enhanced antioxidant potency and autophagy in both cell and Drosophila models.
- Silencing Nrf2 negated the beneficial effects of HEME, indicating its critical role.
Takeaway
This study shows that a mushroom extract can help protect brain cells and improve movement in fruit flies with a genetic disease.
Methodology
The study used human neuroblastoma cells and transgenic Drosophila to assess the effects of the extract on longevity, locomotor activity, and protein aggregation.
Statistical Information
P-Value
p < 0.0001
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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