Anesthetic management in a child with non-ketotic hyperglycinemia
Author Information
Author(s): Mashima Akifumi, Furutani Kenta, Baba Hiroshi
Primary Institution: Niigata University Medical and Dental Hospital
Hypothesis
Can desflurane and nitrous oxide provide better anesthetic management for patients with non-ketotic hyperglycinemia compared to sevoflurane?
Conclusion
Desflurane and nitrous oxide may be preferable anesthetic agents for patients with non-ketotic hyperglycinemia, especially those with a history of delayed emergence from sevoflurane anesthesia.
Supporting Evidence
- The patient experienced no postoperative complications and was discharged on the 14th postoperative day.
- General anesthesia with desflurane and nitrous oxide facilitated early emergence in the patient.
- The patient's EEG showed significant suppression, indicating heightened sensitivity to anesthetics.
Takeaway
This study shows that a special gas called desflurane can help kids with a rare condition wake up faster after surgery compared to another gas called sevoflurane.
Methodology
The patient was given propofol and fentanyl for induction, followed by maintenance with desflurane and nitrous oxide during surgery.
Limitations
The study is based on a single case report, limiting generalizability.
Participant Demographics
A 6-year-old girl with severe non-ketotic hyperglycinemia.
Digital Object Identifier (DOI)
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