Thiram inhibits angiogenesis and slows the development of experimental tumours in mice
2002
Thiram inhibits blood vessel growth and slows tumor development in mice
Sample size: 8
publication
10 minutes
Evidence: high
Author Information
Author(s): Marikovsky M
Primary Institution: Hebrew University of Jerusalem
Hypothesis
Can thiram inhibit angiogenesis and tumor growth in experimental models?
Conclusion
Thiram significantly inhibits angiogenesis and slows the development of tumors in mice.
Supporting Evidence
- Thiram inhibited C6 glioma tumor development by 60%.
- Thiram reduced metastatic growth of Lewis lung carcinoma by 3-5 fold.
- Thiram inhibited angiogenesis by 80-95% in vivo.
Takeaway
Thiram is a chemical that can stop new blood vessels from growing, which helps slow down tumors in mice.
Methodology
The study involved administering thiram to mice and measuring its effects on tumor growth and angiogenesis.
Limitations
The study was conducted in mice, and results may not directly translate to humans.
Participant Demographics
CD1 nude male mice were used in the experiments.
Statistical Information
P-Value
p<0.0003
Statistical Significance
p<0.0003
Digital Object Identifier (DOI)
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