PPARs and Bone Metabolism
2006
PPARs and Bone Metabolism
Editorial
Author Information
Author(s): Beata Lecka-Czernik
Primary Institution: University of Arkansas for Medical Sciences
Hypothesis
PPAR-γ acts as a regulator of chondrocyte development and cartilage homeostasis.
Conclusion
PPAR-γ plays a key role in maintaining bone health during aging and disease.
Supporting Evidence
- PPAR-γ is involved in mesenchymal stem cell lineage allocation.
- There is possible cross-talk between PPAR-γ and relevant nuclear receptors.
- PPAR-γ gene polymorphisms are examined in relation to bone mineral density in humans.
- PPAR-γ is linked to bone loss due to skeletal disuse.
- Human bone is vulnerable to antidiabetic therapies with PPAR-γ agonists.
- The antiosteoblastic activity of PPAR-γ can be separated from its other activities using selective modulators.
Takeaway
PPARs are important for keeping our bones healthy, especially as we get older.
Limitations
Not all aspects of PPARs involvement in bone maintenance are covered.
Digital Object Identifier (DOI)
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