GH-RH Antagonists and Colon Cancer Growth
Author Information
Author(s): Szepeshazi K, Schally A V, Groot K, Armatis P, Halmos G, Hebert F, Szende B, Varga J L, Zarandi M
Primary Institution: Endocrine, Polypeptide and Cancer Institute, Veterans Affairs Medical Center, New Orleans, Louisiana, USA
Hypothesis
Can GH-RH antagonists inhibit the growth of HT-29 human colon cancers by affecting IGF-II production?
Conclusion
GH-RH antagonists significantly inhibit the growth of HT-29 human colon cancers by reducing IGF-II production.
Supporting Evidence
- GH-RH antagonists resulted in a significant 43–45% inhibition of tumor growth.
- Longer acting GH-RH antagonists produced a 43–58% decrease in volume and weight of cancers.
- Histological analyses showed decreased cell proliferation and increased apoptosis in tumors.
Takeaway
This study found that certain drugs can help slow down the growth of colon cancer by stopping the cancer cells from making a substance that helps them grow.
Methodology
Male nude mice with HT-29 human colon cancer xenografts were treated with GH-RH antagonists and tumor growth was measured.
Participant Demographics
Male nude mice
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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