Monitoring Chloroquine Sensitivity of Plasmodium vivax in Thailand
Author Information
Author(s): Muhamad Poonuch, Ruengweerayut Ronnatrai, Chacharoenkul Wanna, Rungsihirunrat Kanchana, Na-Bangchang Kesara
Primary Institution: Thammasat University, Thailand
Hypothesis
Is the clinical efficacy and in vitro sensitivity of Plasmodium vivax to chloroquine stable in the Thai-Myanmar border area?
Conclusion
Chloroquine remains highly effective for treating P. vivax infections in the Thai-Myanmar border, but there are concerns about potential future resistance.
Supporting Evidence
- All patients showed satisfactory response to treatment with a cure rate of virtually 100%.
- There was no recurrence of P. vivax parasitaemia during the investigation period.
- In vitro data showed stable sensitivity of chloroquine in this area since 2006.
- Geometric mean IC50 for chloroquine was 100.1 nM.
Takeaway
Doctors checked if a medicine called chloroquine still works against a type of malaria in Thailand, and it does, but they need to keep watching for any signs that it might stop working.
Methodology
Patients with P. vivax malaria were treated with chloroquine and primaquine, and their responses were monitored over 42 days.
Limitations
The study did not include a control group for chloroquine monotherapy due to ethical reasons.
Participant Demographics
130 patients (64 females, 66 males; 17 Thais, 113 Burmeses) aged 15-60 years.
Statistical Information
Confidence Interval
1.1-264.9 nM
Digital Object Identifier (DOI)
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