Genetic Risk Factors for Lacunar Stroke
Author Information
Author(s): Knottnerus Iris L. H., Gielen Marij, Lodder Jan, Rouhl Rob P. W., Staals Julie, Vlietinck Robert, van Oostenbrugge Robert J.
Primary Institution: Maastricht University Medical Centre
Hypothesis
What is the genetic relative risk of stroke in first-degree relatives of lacunar stroke patients?
Conclusion
The study found an increased genetic relative risk of stroke in first-degree relatives of patients with lacunar stroke.
Supporting Evidence
- Strokes occurred in 13.5% of first-degree relatives of lacunar stroke patients.
- The genetic relative risk was 2.94 for overall first-degree relatives.
- The genetic relative risk was 4.52 for patients' parents.
- The genetic relative risk was 2.10 for patients' siblings.
Takeaway
If someone in your family has had a lacunar stroke, you might be more likely to have a stroke too, because it runs in families.
Methodology
The study involved collecting family history of stroke through questionnaires and comparing it with a community cohort.
Potential Biases
Potential for shared environmental factors influencing familial aggregation of stroke.
Limitations
Self-reported data on family history may not accurately reflect stroke subtypes.
Participant Demographics
The cohort consisted of 195 first-ever lacunar stroke patients, predominantly of native Dutch origin, with a mean age of 63.1 years and 60% male.
Statistical Information
P-Value
0.97 for healthy controls
Confidence Interval
95%CI 2.45–3.53 for overall first-degree relatives
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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