IADLs Predict Plasma NfL Levels in Older Adults Without Dementia
Author Information
Author(s): Li Mengchi, Calderon Russell, Liu Sofia, Li Junxin
Primary Institution: Xi’an Jiaotong University, Johns Hopkins University
Hypothesis
The study aimed to examine the association between Instrumental Activities of Daily Living (IADLs) and plasma Neurofilament light chain (NfL) levels in older adults without dementia.
Conclusion
Higher instrumental activities of daily living were associated with decreased plasma NfL levels in older adults without dementia.
Supporting Evidence
- Higher IADL scores were associated with lower plasma NfL levels.
- 1 point increase in IADLs score was associated with 67% reduced odds of having high NfL.
Takeaway
Doing daily tasks well can mean your brain is healthier, even if you don't have dementia.
Methodology
The study used multiple linear and logistic regression analyses to assess the relationship between IADLs and plasma NfL levels.
Participant Demographics
Participants were aged 65 and older, with 79% females, 61% White American, and 33% Black or African American.
Statistical Information
Confidence Interval
95% CI: -5.99, -2.06
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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