BUB1 and BUBR1: multifaceted kinases of the cell cycle
2011
BUB1 and BUBR1: Key Proteins in Cell Division
publication
Evidence: high
Author Information
Author(s): Victor M. Bolanos-Garcia, Tom L. Blundell
Primary Institution: Department of Biochemistry, University of Cambridge
Conclusion
BUB1 and BUBR1 are essential for accurate chromosome segregation during cell division, and their dysfunction can lead to cancer.
Supporting Evidence
- BUB1 and BUBR1 are crucial for the spindle assembly checkpoint, which prevents chromosome missegregation.
- Mutations in BUB1 and BUBR1 are linked to various cancers, indicating their importance in maintaining genomic stability.
- Structural studies have provided insights into how BUB1 and BUBR1 function at the molecular level.
Takeaway
BUB1 and BUBR1 help make sure that cells divide correctly, so that each new cell gets the right number of chromosomes. If they don't work right, it can cause cancer.
Digital Object Identifier (DOI)
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