The Evolution of the Doublecortin Superfamily
Author Information
Author(s): Reiner Orly, Coquelle Frédéric M, Peter Bastian, Levy Talia, Kaplan Anna, Sapir Tamar, Orr Irit, Barkai Naama, Eichele Gregor, Bergmann Sven
Primary Institution: Weizmann Institute of Science
Hypothesis
How has the DCX superfamily evolved from unicellular organisms to humans?
Conclusion
The study reveals the existence and conservation of multiple members of the DCX superfamily across different species, suggesting that sequence and expression analysis can help predict correlations between human diseases and mouse models.
Supporting Evidence
- Mutations in the DCX gene are linked to brain malformations and other genetic diseases.
- The study identified 22 proteins with DCX domains in human and mouse.
- Expression patterns of DCX proteins were analyzed in various tissues.
- Phylogenetic analysis showed the evolutionary relationships of DCX proteins across species.
Takeaway
This study looks at a family of proteins that help cells move and grow in the brain, showing how they have changed over time in different animals.
Methodology
The study involved phylogenetic analysis, expression profiling, and in situ hybridization to investigate the evolution and expression patterns of the DCX superfamily.
Limitations
The study did not cover all members of the DCX superfamily and focused primarily on specific genes.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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