Induction of arthritis by high mobility group box chromosomal protein 1 is independent of tumour necrosis factor signalling
2008
How HMGB1 Causes Arthritis Without TNF
Sample size: 37
publication
Evidence: moderate
Author Information
Author(s): Pullerits Rille, Jonsson Ing-Marie, Kollias George, Tarkowski Andrej
Primary Institution: Sahlgrenska Academy at Göteborg University
Hypothesis
Is the arthritis-inducing effect of HMGB1 dependent on TNFα expression?
Conclusion
HMGB1-triggered joint inflammation is not mediated via the TNF pathway.
Supporting Evidence
- Injection of HMGB1 resulted in 32% to 39% of mice developing arthritis.
- No significant differences in arthritis severity were found between TNFα knockout and control mice.
- IL-6 production was significantly higher in TNFα+/+ mice compared to TNFα-/- mice when stimulated with HMGB1.
Takeaway
The study found that a protein called HMGB1 can cause arthritis even when another protein, TNF, is not present.
Methodology
Mice were injected with HMGB1 and evaluated for arthritis severity and cytokine response.
Limitations
The study was conducted on a specific mouse strain, which may limit generalizability.
Participant Demographics
Female and male TNFα knockout and control mice.
Statistical Information
P-Value
P < 0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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