Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours
2001
Study of Chemokines in Ovarian Cancer
Sample size: 25
publication
Evidence: moderate
Author Information
Author(s): Scotton C, Milliken D, Wilson J, Raju S, Balkwill F
Primary Institution: ICRF Translational Oncology Laboratory, St Bartholomew's and Royal London School of Medicine and Dentistry
Hypothesis
What is the expression and localization of chemokine receptors in human ovarian tumors?
Conclusion
The study suggests that CCR1 may be a novel therapeutic target in ovarian cancer due to its expression in a majority of tumor samples.
Supporting Evidence
- CCR1 mRNA was detected in samples from 75% of patients.
- CCR1 mRNA localised to macrophages and lymphocytes.
- There was a correlation between numbers of CD8+ and CCR1 expressing cells.
- In vitro, CCR1 mRNA expression was increased 5-fold by hypoxia.
Takeaway
Researchers looked at how certain proteins called chemokines work in ovarian cancer, finding that one type, CCR1, could be important for treatment.
Methodology
The study investigated CC-chemokine receptor expression in 25 biopsies of human ovarian cancer.
Statistical Information
P-Value
0.031
Statistical Significance
p=0.031
Digital Object Identifier (DOI)
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