Study on serum TL1A levels and their correlation with Th17 cells, IL-17 and IL-21 in children with Graves’ disease
Author Information
Author(s): Hao Lijun, Yang Jiong, Lian Biyao, Yin Chunyan, Xiao Yanfeng, Liu Yuesheng
Primary Institution: The Second Affiliated Hospital of Xi’an Jiaotong University
Hypothesis
This study aimed to investigate serum TL1A levels and their correlation with Th17 cells, IL-17, and IL-21 in children with newly diagnosed and untreated Graves’ disease.
Conclusion
Serum TL1A levels are increased in children with Graves’ disease and positively correlate with Th17 cells, IL-17, and IL-21.
Supporting Evidence
- Serum TL1A levels were significantly higher in children with Graves’ disease compared to healthy controls.
- Serum IL-17 and IL-21 levels were also significantly elevated in Graves’ disease patients.
- Serum TL1A levels positively correlated with the percentage of Th17 cells, IL-17, and IL-21.
Takeaway
The study found that kids with Graves' disease have higher levels of a protein called TL1A, which is linked to certain immune cells and chemicals that can cause inflammation.
Methodology
The study measured serum TL1A, IL-17, and IL-21 levels using ELISA and determined Th17 cell percentages by flow cytometry in 37 children with Graves’ disease.
Limitations
The sample size was relatively small, and the cross-sectional design does not allow for causality determination.
Participant Demographics
The study included 37 children (12 males and 25 females) aged 9-14 years with newly diagnosed and untreated Graves’ disease.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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